To work with ConstraintLayout, you need Android Studio Version 2.2 or newer and have at least version 32 (or higher) of Android Support Repository.

1. Add the Constraint Layout library as a dependency in your build.gradle file:

dependencies {
   compile 'com.android.support.constraint:constraint-layout:1.0.2'
}

2. Sync project

To add a new constraint layout to your project:

1. Right-click on your module's layout directory, then click New > XML > Layout XML.
2. Enter a name for the layout and enter "android.support.constraint.ConstraintLayout" for the Root Tag.
3. Click Finish.

Otherwise just add in a layout file:

<?xml version="1.0" encoding="utf-8"?>
<android.support.constraint.ConstraintLayout
    xmlns:android="http://schemas.android.com/apk/res/android"
    xmlns:app="http://schemas.android.com/apk/res-auto"
    android:layout_width="match_parent"
    android:layout_height="match_parent">

</android.support.constraint.ConstraintLayout>

Since ConstraintLayout alpha 9, Chains are available. A Chain is a set of views inside a ConstraintLayout that are connected in a bi-directional way between them, i.e A connected to B with a constraint, and B connected to A with another constraint.

Example:

<android.support.constraint.ConstraintLayout
    xmlns:android="http://schemas.android.com/apk/res/android"
    xmlns:app="http://schemas.android.com/apk/res-auto"
    android:layout_width="match_parent"
    android:layout_height="match_parent">

    <!-- this view is linked to the bottomTextView --> 
    <TextView
        android:id="@+id/topTextView"
        android:layout_width="wrap_content"
        android:layout_height="wrap_content"
        android:text="TextView"
        app:layout_constraintBottom_toTopOf="@+id/bottomTextView"
        app:layout_constraintTop_toTopOf="parent"
        app:layout_constraintVertical_chainPacked="true"/>

    <!-- this view is linked to the topTextView at the same time --> 
    <TextView
        android:id="@+id/bottomTextView"
        android:layout_width="wrap_content"
        android:layout_height="wrap_content"
        android:text="Bottom\nMkay"
        app:layout_constraintBottom_toBottomOf="parent"
        app:layout_constraintTop_toBottomOf="@+id/topTextView"/>

</android.support.constraint.ConstraintLayout>

In this example, the two views are positioned one under another and both of them are centered vertically. You may change the vertical position of these views by adjusting the chain's bias. Add the following code to the first element of a chain:

app:layout_constraintVertical_bias="0.2"

In a vertical chain, the first element is a top-most view, and in a horizontal chain it is the left-most view. The first element defines the whole chain's behavior.

Chains are a new feature and are updated frequently. Here is an official Android Documentation on Chains.