Well, if you want a switch/case construct, the most straightforward way to go is to use the good old if/else construct:

def switch(value):
    if value == 1:
        return "one"
    if value == 2:
        return "two"
    if value == 42:
        return "the answer to the question about life, the universe and everything"
    raise Exception("No case found!")

it might look redundant, and not always pretty, but that's by far the most efficient way to go, and it does the job:

>>> switch(1)
one
>>> switch(2)
two
>>> switch(3)
…
Exception: No case found!
>>> switch(42)
the answer to the question about life the universe and everything

Another straightforward way to go is to create a dictionary of functions:

switch = {
    1: lambda: 'one',
    2: lambda: 'two',
    42: lambda: 'the answer of life the universe and everything',
}

then you add a default function:

def default_case():
    raise Exception('No case found!')

and you use the dictionary's get method to get the function given the value to check and run it. If value does not exists in dictionary, then default_case is run.

>>> switch.get(1, default_case)()
one
>>> switch.get(2, default_case)()
two
>>> switch.get(3, default_case)()
…
Exception: No case found!
>>> switch.get(42, default_case)()
the answer of life the universe and everything

you can also make some syntactic sugar so the switch looks nicer:

def run_switch(value):
    return switch.get(value, default_case)()

>>> run_switch(1)
one

You can use a class to mimic the switch/case structure. The following is using introspection of a class (using the getattr() function that resolves a string into a bound method on an instance) to resolve the "case" part.

Then that introspecting method is aliased to the __call__ method to overload the () operator.

class SwitchBase:
    def switch(self, case):
        m = getattr(self, 'case_{}'.format(case), None)
        if not m:
            return self.default
        return m

    __call__ = switch

Then to make it look nicer, we subclass the SwitchBase class (but it could be done in one class), and there we define all the case as methods:

class CustomSwitcher:
    def case_1(self):
        return 'one'

    def case_2(self):
        return 'two'

    def case_42(self):
        return 'the answer of life, the universe and everything!'

    def default(self):
        raise Exception('Not a case!')

so then we can finally use it:

>>> switch = CustomSwitcher()
>>> print(switch(1))
one
>>> print(switch(2))
two
>>> print(switch(3))
…
Exception: Not a case!
>>> print(switch(42))
the answer of life, the universe and everything!

Another way, which is very readable and elegant, but far less efficient than a if/else structure, is to build a class such as follows, that will read and store the value to compare with, expose itself within the context as a callable that will return true if it matches the stored value:

class Switch:
    def __init__(self, value): 
        self._val = value
    def __enter__(self):
        return self
    def __exit__(self, type, value, traceback):
        return False # Allows traceback to occur
    def __call__(self, cond, *mconds): 
        return self._val in (cond,)+mconds

then defining the cases is almost a match to the real switch/case construct (exposed within a function below, to make it easier to show off):

def run_switch(value):
    with Switch(value) as case:
        if case(1):
            return 'one'
        if case(2):
            return 'two'
        if case(3):
            return 'the answer to the question about life, the universe and everything'
        # default
        raise Exception('Not a case!')

So the execution would be:

>>> run_switch(1)
one
>>> run_switch(2)
two
>>> run_switch(3)
…
Exception: Not a case!
>>> run_switch(42)
the answer to the question about life, the universe and everything

Nota Bene:

• This solution is being offered as the switch module available on pypi.